Notes

1. Tropocollagen
   1. Formation is an extracellular event (done by endopeptidases)
   2. MW = 300,000
   3. Hydroxy, glycos occur intracellular (before tropo is formed)
2. Methotrexate
   1. Drug used to treat cancer and autoimmune diseases; inhibits metabolism of folic acid, thus DNA synthesis
3. Sweet, salty, sour, bitter  which has the lowest threshold
   1. BITTER
4. cDNA = complementary DNA from mature mRNA in a reaction from reverse transcriptase; can be used to clone
   1. Remember introns are splice out, exons stay in
5. tRNA = has the anticodon to mRNA and goes and picks up and transfers corresponding amino acids to add to growing chain
6. PCo2 = 24; normal should be 40; then Hco3 bicarb level is also low. What is wrong?
   1. Chronic/acute & metabolic/respiratory  alkalosis…
   2. If HCO3 is less than about 20 meq/L than it is alkalosis
   3. PCo2 < 20 = acute respiratory
   4. PCo2 >20<40 = chronic respiratory alkalosis
   5. PCo2 >40<60 = chronic metabolic
7. Spike in arterial blood pressure how does body adjust? What compensation?
   1. Parasympathetic to slow HR
8. Maybe asked something about PFK (phosphofructokinase)
   1. Regulates glycolysis allosterically; rate limiting step; converts Fructose 6-phosphate to fructose 1,6-bisphosphate
9. RQ (respiratory quotient) of 0.7 what does that mean?
   1. Burning fats
   2. 1 = carbs; 0.8-0.9 = proteins
10. PAH  Renal plasma flow
    1. Inulin/CP  GFR
11. Chylomicrons flow through lymph system
12. Isotope = same atomic #, but different mass numbers
13. Miosis is parasympathetic  will constrict pupils
    1. Myadrasis sympathetic  dilate
14. Fructose does Levans; glucose does dextrans